Microdosing & Nano-dosing Cannabis
I like to start simple and with the basics, what is microdosing?
“Microdosing (or micro-dosing) is a technique for studying the behaviour of drugs in humans through the administration of doses so low (“sub-therapeutic”) they are unlikely to produce whole-body effects, but high enough to allow the cellular response to be studied.”
Doctors are discovering we each have a threshold dose which if we maintain our intake below that threshold, it has been noted that patients experience an increase of health benefits. Whereas consuming above that level has shown the potential of diminishing benefits, more side effects and building tolerance. In certain cases cancer patients using less than the recommended dose of RSO are responding more positively and heavy doses were showing a worsening of the situation.(1) How does one try microdosing? Start with taking a very measured dose of THC, of around 5 to 10 milligrams. The easiest method being edibles or tinctures, low dose or small dosed portions. Read the label, understand portion dosing. I like tinctures, alcohol based to be specific. An oral application directly under the tongue produces effects in minutes and is a simple method of controlled dosing. Successful edible makers understand this concept. Brands like Kiva state, “We believe that in a couple years microdosing is going to be the most popular way people use cannabis…In the same way we take vitamin C and zinc to avoid getting sick, we will be taking cannabis to stay healthy and safely manage stress and anxiety.”(2)
What is nano dosing or nanoemulsions?
The National Center for Biotechnology Information tells us:
“Nanoemulsions are nano-sized emulsions, which are manufactured for improving the delivery of active pharmaceutical ingredients. These are the thermodynamically stable isotropic system in which two immiscible liquids are mixed to form a single phase by means of an emulsifying agent, i.e., surfactant and co-surfactant. The droplet size of nanoemulsion falls typically in the range 20–200 nm. The main difference between emulsion and nanoemulsion lies in the size and shape of particles dispersed in the continuous phase.”
Cannabinoids have a very low absorption rate when taken orally.(3) My understanding of nano dosing is it is a high tech, advanced delivery system. Cannabinoids that have undergone this process are broken down on a molecular level that allows them to be more beneficial with increased absorption and minimize adverse reaction for low doses. It also allows for precise metered dosing, it can enter the bloodstream in 15 minutes and reach peak dosing in an hour.(4) Available nano dosed products such as CBD crystal isolate, are water soluble and can be added to any food or beverage.(5) There are some nano infused cannabis edibles available on the market now such as CBD Naturals water and CannaPunch gummies.
To whom and why dosing in this way is appealing?
Upon consuming lower doses in this manner one may not feel “high” yet benefit from a side effect free, mind opening experience. Patients who suffer from anxiety as a side effect or don’t like the head high feeling may benefit from lower dosage consumption. As a patient looking to make a change from traditional medicine to cannabis treatment lower dosing may be appealing as well.(6)
I hope you enjoyed this introduction to micro/nano dosing cannabis, please check out the following links for more information: