Product Spotlight- Giggle Therapeutics

Have you heard about THCa?

We want to talk to you about Giggle Therapeutics!

Pictured above you see Giggle Therapeutics Vita-Mini Giggle tablets. The THCa chewables with Vitamin C, Rosehips & Cordyceps will usher in a whole new level of relief for patients suffering from pain & inflammation without a “high”.

They also make a THCa frosting that is edible and combustible! Just remember once you add heat to THCa the psychotropic effects will become activated.

Why THCa?

“Studies have found THCA to have anti-inflammatory, neuro-protective, anti-emetic, and anti-proliferative properties, all which could make it medically beneficial for a range of conditions. This variety of potential medicinal benefits could make THCA an important cannabinoid for patients with a variety of medical conditions that already benefit from marijuana. Its anti-inflammatory properties could make it beneficial for those with pain, muscle spasms, PMS related cramping, or auto-immune conditions.” quoted from HelloMD

 

Visit their website here:

Cannabis Edibles | California | Giggle Therapeutics

 

Eating your cannabis, what is microdosing & nano-dosing?

Microdosing & Nano-dosing Cannabis


I like to start simple and with the basics, what is microdosing?

Wikipedia states:

“Microdosing (or micro-dosing) is a technique for studying the behaviour of drugs in humans through the administration of doses so low (“sub-therapeutic”) they are unlikely to produce whole-body effects, but high enough to allow the cellular response to be studied.”

Doctors are discovering we each have a threshold dose which if we maintain our intake below that threshold, it has been noted that patients experience an increase of health benefits. Whereas consuming above that level has shown the potential of diminishing benefits, more side effects and building tolerance. In certain cases cancer patients using less than the recommended dose of RSO are responding more positively and heavy doses were showing a worsening of the situation.(1)  How does one try microdosing? Start with taking a very measured dose of THC, of around 5 to 10 milligrams. The easiest method being edibles or tinctures, low dose or small dosed portions. Read the label, understand portion dosing. I like tinctures, alcohol based to be specific. An oral application directly under the tongue produces effects in minutes and is a simple method of controlled dosing. Successful edible makers understand this concept. Brands like Kiva state, “We believe that in a couple years microdosing is going to be the most popular way people use cannabis…In the same way we take vitamin C and zinc to avoid getting sick, we will be taking cannabis to stay healthy and safely manage stress and anxiety.”(2)  


What is nano dosing or nanoemulsions?

The National Center for Biotechnology Information tells us:

“Nanoemulsions are nano-sized emulsions, which are manufactured for improving the delivery of active pharmaceutical ingredients. These are the thermodynamically stable isotropic system in which two immiscible liquids are mixed to form a single phase by means of an emulsifying agent, i.e., surfactant and co-surfactant. The droplet size of nanoemulsion falls typically in the range 20–200 nm. The main difference between emulsion and nanoemulsion lies in the size and shape of particles dispersed in the continuous phase.

Cannabinoids have a very low absorption rate when taken orally.(3) My understanding of nano dosing is it is a high tech, advanced delivery system. Cannabinoids that have undergone this process are broken down on a molecular level that allows them to be more beneficial with increased absorption and minimize adverse reaction for low doses. It also allows for precise metered dosing, it can enter the bloodstream in 15 minutes and reach peak dosing in an hour.(4) Available nano dosed products such as CBD crystal isolate, are water soluble and can be added to any food or beverage.(5)  There are some nano infused cannabis edibles available on the market now such as CBD Naturals water and CannaPunch gummies.


To whom and why dosing in this way is appealing?

Upon consuming lower doses in this manner one may not feel “high” yet benefit from a side effect free, mind opening experience. Patients who suffer from anxiety as a side effect or don’t like the head high feeling may benefit from lower dosage consumption. As a patient looking to make a change from traditional medicine to cannabis treatment lower dosing may be appealing as well.(6)

I hope you enjoyed this introduction to micro/nano dosing cannabis, please check out the following links for more information:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362737/

http://www.nature.com/nmeth/journal/v11/n9/full/nmeth.3062.html

http://www.nanowerk.com/nanotechnology-news/newsid=37246.php


References
  1. https://www.learngreenflower.com/articles/52/less-is-more-micro-dosing-and-medical-cannabis
  2. http://mashable.com/2016/11/11/marijuana-microdosing/#AE03w_3YZSqu
  3. http://www.prweb.com/releases/2015/06/prweb12780796.htm
  4. http://www.nanospherehealth.com/news/2016/6/21/nanotechnology-cannabis-why-we-need-a-delivery-system
  5. http://blog.sonomechanics.com/blog/ultrasonic-production-of-nano-cannabinoids
  6. https://www.merryjane.com/health/how-and-why-you-should-microdose-cannabis

 

Eating your cannabis, How are edibles infused? Understanding infusion.

Let’s talk about eating your cannabis – Part II – Understanding infusion & ingestion.

How are edibles infused?

I would like to begin with my original resource and favored acquisition, The Cannabis Kitchen Cookbook by Robyn Griggs Lawrence. If you do not have a copy and intend to cook with cannabis I highly recommend you pick up a copy, a well rounded source on using cannabis for cooking.

Edible extraction science simply put is that honey, milk, oils, and butters all bind with THC-a and CBD-a, when heated gently they extract the cannabinoids and terpenes from the plant matter and convert them into THC and CBD. Alcohol and glycerin maceration may also be used to extract cannabinoids, heating increases processing time and potency with this method.

I will cover the topic to the best of my knowledge, I am not a doctor nor a culinary professional, the following is my understanding of the data available to me.


Raw Cannabis

In its natural state is infused and includes plenty of terpenes, antioxidants, and anti-inflammatory treating CBD, a complete protein containing omega fatty acids and essential amino acids. Patients can juice raw cannabis fan leaves or eat raw cannabis flower daily allowing them the therapeutic benefit with little to no psychotropic effect. Leaves can be juiced or chopped and added to salads, flowers are recommended to blend into smoothies or juice, cannabis is bitter it is recommended to complement accordingly with your ingredients to achieve the best flavor. Cannabis seeds fall under raw cannabis, minimal THC content with a nut butter taste. Easy to consume and can be eaten shelled like sunflowers seeds or ground into powder and mixed into oils. The golden rule of edibles applies for raw cannabis as well, start low, go slow; Effects may take 1-3 hours.

We have come to learn that cannabis high in THCa, the acidic, raw, non-psychotropic form of THC has been shown to have immensely successful therapeutic value. This value is appreciated by those treating children with cannabis.(1) Consuming unactivated THC-acid therapies is great for many older patients looking for an alternative to the “high” but still getting the benefits of treatment. Patients treating with MS, ALS, autism and fibromyalgia report successful anecdotal results from THCa therapies.(2)  THCa has also been proven to be of medicinal benefit to those dealing with nausea.(3)(4)

THCa sublingual tinctures can be found at most dispensaries.


Oils & Butters

These cooking fats are commonly used in most edibles. They are infused by heating the cured cannabis, your selected fat and water together, then straining out the infused fat/oil from the water and plant matter. Ratios depend on desired potency and will vary batch to batch. For optimal infusions the method is low and slow at no more than 200 degrees fahrenheit. Ghee infused with cannabis is another option for the lactose intolerant and can be stored unrefrigerated for up to 6 weeks. All of these vehicles offer the means to add activated cannabis to any meal.
The effects of THC are intensified by protein rich, fatty foods, they come on fast and diminish quickly with sugar and when THC is mixed with alcohol it may cause paranoia. When baking with infused fats never exceed 300 degrees fahrenheit and increase cooking time by 50 percent.(5) Every time you heat your infused butter or oil you run the risk of burning off cannabinoids so know that. THC that is processed through the liver last longer and is more potent. Many patients look to edibles as alternative to smoking cannabis but find the inconsistency in dosing problematic.


Concentrates

Concentrates are typically infused over a low heat melting into oil or butter. Using concentrates reduces the herbal flavor and are far more potent than using plant matter. Solventless products are preferred for health reasons, bubble hash and dry sift being optimal. When working with waxes and other firm concentrates may require more effort in the beginning dissolving the concentrate but little straining of impurities at the end of the process.(6) Some edibles are made with concentrate infused oil/butter and some have cannabis oil sprayed on top(7). Keif is the powder in the bottom of your grinder, trichomes from your cannabis. Hash is heated and pressed trichomes. When using hash or kief, once decarbed, they can be added directly into the recipe or food in some cases. (8)

There are many edibles on the market infused with concentrates, read labels, ask questions; How was the concentrate processed or where was it sourced from? Edibles made with concentrates tend to be more potent with a quicker onset, with edibles effect already being more potent, and with longer lasting effects should all be taken under consideration. 


These are important things to know and understand about edibles. We need to know how edibles are infused and what we are putting into our bodies. How was the cannabis in your edible processed? Use this information to make the best treatment choice for optimal results. There are various appeals to edibles beyond that of those looking to not smoke. Edibles effects last longer and therapeutic benefits outlast the high, raw cannabis and cannabis seed add another layer to holistic nutrition aspects and if you are looking for a potent edible try one infused with concentrate. 
Thank you for your interest in learning more about how cannabis edibles are infused. Next week we will discuss micro and nano dosing.


References:
***Get your CookBook here!***
Making our own THCA medicine for pediatric epilepsy  (1)
Pure Analytics (2)
Getting familiar with THC (3)
THCa and CBDa (4)
Medical Jane (5)
The Cannabist (6)
The Denver Post (7)
Cannabis Cheri (8)

 

Eating your Cannabis, How ingestion differs from other methods

Let’s talk about eating your cannabis – Part I – Ingestion vs. Inhalation

Sounds a little ridiculous doesn’t it? But ingesting your medicine is a whole new ball game, as well as an arena with much potential for patient care. There has been a lot of discussion surrounding edibles, usually stories about over-medicating, ranging from the hilarious to the terrifying. It was with this in mind that I went a-researching.


Eating your medicine, The Basics.

My first stop, a non-cannabis source for a basic understanding of the process, of course was Wikipedia. (Keep it simple.)

11-Hydroxy-Δ9-tetrahydrocannabinol (11-OH-THC) is the main active metabolite of Tetrahydrocannabinol (THC) which is formed in the body after cannabis is consumed.[1] The conversion from THC to 11-OH-THC is relatively high when cannabis is consumed in the form of cannabis edibles and, compared to oral consumption, lower when it is smoked or vaped.[2] 11-OH-THC is more potent than THC and crosses the blood–brain barrier more easily.[3][4] 11-Hydroxy-THC has been shown to be active in its own right.[5][6] This might partially explain the biphasic effects of cannabis, whereby some effects such as increased appetite tend to be delayed rather than occurring immediately when the drug is consumed.[7]

Fresh cannabis contains Tetrahydrocannabinolic acid (THCA), which is converted into THC after heating and then metabolized by the body into 11-Hydroxy-THC.[8][9][10][11] Peak THC concentrations are lower after eating/drinking cannabis than after administration by smoking or vaping, but conversely, 11-OH-THC/THC ratios are higher after eating/drinking than after smoking cannabis.[12] After administration through eating or drinking, approximately equal quantities of THC and 11-OH-THC are formed, whereas 11-OH-THC is a minor constituent after administration by intravenous or smoking routes.[13] Because edible doses are processed by the liver before entering the bloodstream, THC consumed as edibles produces high levels of 11-OH-THC, while smoked cannabis, which goes directly from the lungs to the brain via the bloodstream and does not enter the liver,[14] produces lower levels.[15]

11-Hydroxy-THC is subsequently metabolised further to 11-nor-9-carboxy-THC, which is not psychoactive but might still play a role in the analgesic and anti-inflammatory effects of cannabis.

 

Well all right then, you catch all that?

What we have come to know is that ingested cannabis that is metabolized by one’s liver provides a different experience with various effects. For example, a longer onset but with longer duration. Also the effects are stronger and therapeutic benefits outlast the “high” once metabolised further. Patients treating chronic pain and inflammatory conditions may do well to consider edibles as a treatment option.


The Essentials

HelloMD has a great article on edibles, I will post it below. It covers the essentials of edibles: Understand potency, How long to wait and Read the label! All of these will help you to determine your dose and schedule in addition to preparing you for the results.

https://www.hellomd.com/health-wellness/essentials-about-edibles-that-you-need-to-know

Something notable in selecting your edible I would like to mention is processing and strains. There is such a flood of edibles on the market, from homemade to recognized brands to luxury cannabis cuisine, I do not want anyone overlooking the obvious. Is the cannabis lab-tested? Where is it sourced? How is it processed? Is the edible lab-tested? What strain(s) is/are being used?


Regulation, its coming.

This is a tipping point for edibles in California, with the passage of Prop 64 these companies must fall into compliance or be forced out of business. Admittedly a necessary action for consumer safety but also financially punitive for those who wish to participate as a business in the state cannabis industry. Notably any direction from the state on these matters is still forthcoming leaving current business to tread water and hopefully seek counsel on next steps.

My advice, only consume lab-tested edibles, preferably tested as the edible not just lab-tested cannabis or cannabis concentrate used on the edible. These are not currently regulated and we must be proactive in protecting ourselves. Just recently a Los Angeles media source ran a piece on random cannabis products being sold in dispensaries as safe, lab-tested cannabis. A disturbing 84% of samples collected from all over the city of Los Angeles tested positive for pesticides in an independent test from Steep Hill Labs. It was disappointing to see some really respected brands on this list, if anything reaffirming the need to educate yourself.

http://www.nbclosangeles.com/investigations/I-Team-Marijuana-Pot-Pesticide-California-414536763.html


Strain profiles

On to cannabis strains! It is worth mentioning that what we know about certain strains of cannabis flower or concentrate may not cross over into edible treatments. Depending on processing, application and formulations the effects can widely vary in comparison to your smoking or vaping experience. For example the breakdown of certain cannabinoids and terpenes will impact the overall profile, thus my recommendation to have the edibles lab-tested. Check out The Cannabist’s article on edibles from 2016 here:

http://www.thecannabist.co/2015/05/07/marijuana-edibles-vs-smoking-pot/34486/

It is still early and many more companies are lab-testing as well as planning for state compliance in many ways. One of my favorites as of late is the addition of a QR code right on the product label in which you get immediate access to that product batch lab-test results. It is really fun when the vendor goes for the FULL testing profile complete with terpene, heavy metals and pesticide analysis!


In Summary

Eating your cannabis may be the way to go if you do not want to smoke, have a condition that prevents one from smoking or feel more comfortable consuming in food. Understanding the differences in medicating only increase your ability to provide yourself with optimal care. This also opens the door to making your own medicine by cooking with cannabis and normalizing your treatment. Maybe you would rather make a batch of infused preserves to spread on toast each morning versus taking a pill, just one of many examples. This also solves the issue of sourcing and processing, especially if you have your own personal cannabis grow.

 

Check back soon for more on, Eating your Cannabis.