Product Spotlight- Giggle Therapeutics

Have you heard about THCa?

We want to talk to you about Giggle Therapeutics!

Pictured above you see Giggle Therapeutics Vita-Mini Giggle tablets. The THCa chewables with Vitamin C, Rosehips & Cordyceps will usher in a whole new level of relief for patients suffering from pain & inflammation without a “high”.

They also make a THCa frosting that is edible and combustible! Just remember once you add heat to THCa the psychotropic effects will become activated.

Why THCa?

“Studies have found THCA to have anti-inflammatory, neuro-protective, anti-emetic, and anti-proliferative properties, all which could make it medically beneficial for a range of conditions. This variety of potential medicinal benefits could make THCA an important cannabinoid for patients with a variety of medical conditions that already benefit from marijuana. Its anti-inflammatory properties could make it beneficial for those with pain, muscle spasms, PMS related cramping, or auto-immune conditions.” quoted from HelloMD

 

Visit their website here:

Cannabis Edibles | California | Giggle Therapeutics

 

Eating your cannabis, what is microdosing & nano-dosing?

Microdosing & Nano-dosing Cannabis


I like to start simple and with the basics, what is microdosing?

Wikipedia states:

“Microdosing (or micro-dosing) is a technique for studying the behaviour of drugs in humans through the administration of doses so low (“sub-therapeutic”) they are unlikely to produce whole-body effects, but high enough to allow the cellular response to be studied.”

Doctors are discovering we each have a threshold dose which if we maintain our intake below that threshold, it has been noted that patients experience an increase of health benefits. Whereas consuming above that level has shown the potential of diminishing benefits, more side effects and building tolerance. In certain cases cancer patients using less than the recommended dose of RSO are responding more positively and heavy doses were showing a worsening of the situation.(1)  How does one try microdosing? Start with taking a very measured dose of THC, of around 5 to 10 milligrams. The easiest method being edibles or tinctures, low dose or small dosed portions. Read the label, understand portion dosing. I like tinctures, alcohol based to be specific. An oral application directly under the tongue produces effects in minutes and is a simple method of controlled dosing. Successful edible makers understand this concept. Brands like Kiva state, “We believe that in a couple years microdosing is going to be the most popular way people use cannabis…In the same way we take vitamin C and zinc to avoid getting sick, we will be taking cannabis to stay healthy and safely manage stress and anxiety.”(2)  


What is nano dosing or nanoemulsions?

The National Center for Biotechnology Information tells us:

“Nanoemulsions are nano-sized emulsions, which are manufactured for improving the delivery of active pharmaceutical ingredients. These are the thermodynamically stable isotropic system in which two immiscible liquids are mixed to form a single phase by means of an emulsifying agent, i.e., surfactant and co-surfactant. The droplet size of nanoemulsion falls typically in the range 20–200 nm. The main difference between emulsion and nanoemulsion lies in the size and shape of particles dispersed in the continuous phase.

Cannabinoids have a very low absorption rate when taken orally.(3) My understanding of nano dosing is it is a high tech, advanced delivery system. Cannabinoids that have undergone this process are broken down on a molecular level that allows them to be more beneficial with increased absorption and minimize adverse reaction for low doses. It also allows for precise metered dosing, it can enter the bloodstream in 15 minutes and reach peak dosing in an hour.(4) Available nano dosed products such as CBD crystal isolate, are water soluble and can be added to any food or beverage.(5)  There are some nano infused cannabis edibles available on the market now such as CBD Naturals water and CannaPunch gummies.


To whom and why dosing in this way is appealing?

Upon consuming lower doses in this manner one may not feel “high” yet benefit from a side effect free, mind opening experience. Patients who suffer from anxiety as a side effect or don’t like the head high feeling may benefit from lower dosage consumption. As a patient looking to make a change from traditional medicine to cannabis treatment lower dosing may be appealing as well.(6)

I hope you enjoyed this introduction to micro/nano dosing cannabis, please check out the following links for more information:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362737/

http://www.nature.com/nmeth/journal/v11/n9/full/nmeth.3062.html

http://www.nanowerk.com/nanotechnology-news/newsid=37246.php


References
  1. https://www.learngreenflower.com/articles/52/less-is-more-micro-dosing-and-medical-cannabis
  2. http://mashable.com/2016/11/11/marijuana-microdosing/#AE03w_3YZSqu
  3. http://www.prweb.com/releases/2015/06/prweb12780796.htm
  4. http://www.nanospherehealth.com/news/2016/6/21/nanotechnology-cannabis-why-we-need-a-delivery-system
  5. http://blog.sonomechanics.com/blog/ultrasonic-production-of-nano-cannabinoids
  6. https://www.merryjane.com/health/how-and-why-you-should-microdose-cannabis

 

Eating your cannabis, How are edibles infused? Understanding infusion.

Let’s talk about eating your cannabis – Part II – Understanding infusion & ingestion.

How are edibles infused?

I would like to begin with my original resource and favored acquisition, The Cannabis Kitchen Cookbook by Robyn Griggs Lawrence. If you do not have a copy and intend to cook with cannabis I highly recommend you pick up a copy, a well rounded source on using cannabis for cooking.

Edible extraction science simply put is that honey, milk, oils, and butters all bind with THC-a and CBD-a, when heated gently they extract the cannabinoids and terpenes from the plant matter and convert them into THC and CBD. Alcohol and glycerin maceration may also be used to extract cannabinoids, heating increases processing time and potency with this method.

I will cover the topic to the best of my knowledge, I am not a doctor nor a culinary professional, the following is my understanding of the data available to me.


Raw Cannabis

In its natural state is infused and includes plenty of terpenes, antioxidants, and anti-inflammatory treating CBD, a complete protein containing omega fatty acids and essential amino acids. Patients can juice raw cannabis fan leaves or eat raw cannabis flower daily allowing them the therapeutic benefit with little to no psychotropic effect. Leaves can be juiced or chopped and added to salads, flowers are recommended to blend into smoothies or juice, cannabis is bitter it is recommended to complement accordingly with your ingredients to achieve the best flavor. Cannabis seeds fall under raw cannabis, minimal THC content with a nut butter taste. Easy to consume and can be eaten shelled like sunflowers seeds or ground into powder and mixed into oils. The golden rule of edibles applies for raw cannabis as well, start low, go slow; Effects may take 1-3 hours.

We have come to learn that cannabis high in THCa, the acidic, raw, non-psychotropic form of THC has been shown to have immensely successful therapeutic value. This value is appreciated by those treating children with cannabis.(1) Consuming unactivated THC-acid therapies is great for many older patients looking for an alternative to the “high” but still getting the benefits of treatment. Patients treating with MS, ALS, autism and fibromyalgia report successful anecdotal results from THCa therapies.(2)  THCa has also been proven to be of medicinal benefit to those dealing with nausea.(3)(4)

THCa sublingual tinctures can be found at most dispensaries.


Oils & Butters

These cooking fats are commonly used in most edibles. They are infused by heating the cured cannabis, your selected fat and water together, then straining out the infused fat/oil from the water and plant matter. Ratios depend on desired potency and will vary batch to batch. For optimal infusions the method is low and slow at no more than 200 degrees fahrenheit. Ghee infused with cannabis is another option for the lactose intolerant and can be stored unrefrigerated for up to 6 weeks. All of these vehicles offer the means to add activated cannabis to any meal.
The effects of THC are intensified by protein rich, fatty foods, they come on fast and diminish quickly with sugar and when THC is mixed with alcohol it may cause paranoia. When baking with infused fats never exceed 300 degrees fahrenheit and increase cooking time by 50 percent.(5) Every time you heat your infused butter or oil you run the risk of burning off cannabinoids so know that. THC that is processed through the liver last longer and is more potent. Many patients look to edibles as alternative to smoking cannabis but find the inconsistency in dosing problematic.


Concentrates

Concentrates are typically infused over a low heat melting into oil or butter. Using concentrates reduces the herbal flavor and are far more potent than using plant matter. Solventless products are preferred for health reasons, bubble hash and dry sift being optimal. When working with waxes and other firm concentrates may require more effort in the beginning dissolving the concentrate but little straining of impurities at the end of the process.(6) Some edibles are made with concentrate infused oil/butter and some have cannabis oil sprayed on top(7). Keif is the powder in the bottom of your grinder, trichomes from your cannabis. Hash is heated and pressed trichomes. When using hash or kief, once decarbed, they can be added directly into the recipe or food in some cases. (8)

There are many edibles on the market infused with concentrates, read labels, ask questions; How was the concentrate processed or where was it sourced from? Edibles made with concentrates tend to be more potent with a quicker onset, with edibles effect already being more potent, and with longer lasting effects should all be taken under consideration. 


These are important things to know and understand about edibles. We need to know how edibles are infused and what we are putting into our bodies. How was the cannabis in your edible processed? Use this information to make the best treatment choice for optimal results. There are various appeals to edibles beyond that of those looking to not smoke. Edibles effects last longer and therapeutic benefits outlast the high, raw cannabis and cannabis seed add another layer to holistic nutrition aspects and if you are looking for a potent edible try one infused with concentrate. 
Thank you for your interest in learning more about how cannabis edibles are infused. Next week we will discuss micro and nano dosing.


References:
***Get your CookBook here!***
Making our own THCA medicine for pediatric epilepsy  (1)
Pure Analytics (2)
Getting familiar with THC (3)
THCa and CBDa (4)
Medical Jane (5)
The Cannabist (6)
The Denver Post (7)
Cannabis Cheri (8)